{"entity_type":"fund","name":"Janus Henderson Global Life Sciences Fund","identifiers":{"lei":"5493001MPP2BKRJEGV73","cik":"277751","fund_id":"S000010494","fundkey":"janus-henderson-global-life-sciences-fund"},"dates":{"reporting_period_start":"2025-12-31","reporting_period_end":"2026-09-30","filing_date":"2026-02-27"},"summary":{"total_positions":106,"total_value_usd":5352958219.29,"asset_categories":["EP","EC"],"by_asset_category":{"EC":{"positions":83,"total_value_usd":4740713440.75},"EP":{"positions":16,"total_value_usd":151295493.25},"Unknown":{"positions":7,"total_value_usd":460949285.29}}},"holdings":[{"issuer_name":"Eli Lilly & Co.","title":"Eli Lilly & Co. COM NPV","isin":"US5324571083","value_usd":517209094.24,"pct_val":9.6495927309,"balance":481268,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Johnson & Johnson","title":"Johnson & Johnson COM USD1.00","isin":"US4781601046","value_usd":298945897.4,"pct_val":5.577446705,"balance":1444532,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"AstraZeneca PLC","title":"AstraZeneca PLC ORD USD0.25","isin":"GB0009895292","value_usd":228446409.25,"pct_val":4.2621346659,"balance":1240485,"units":"NS","currency":null,"asset_cat":"EC","issuer_cat":"CORP","inv_country":"GB","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"UnitedHealth Group Inc.","title":"UnitedHealth Group Inc. COM USD0.01","isin":"US91324P1021","value_usd":184092113.59,"pct_val":3.4346146286,"balance":557669,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"AbbVie Inc.","title":"AbbVie Inc. COM USD0.01","isin":"US00287Y1091","value_usd":181533477.08,"pct_val":3.3868780351,"balance":794492,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Abbott Laboratories","title":"Abbott Laboratories COM NPV","isin":"US0028241000","value_usd":141652748.71,"pct_val":2.6428215387,"balance":1130599,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Argenx SE","title":"Argenx SE SPON ADR EACH REP 1 ORD SHS","isin":"US04016X1019","value_usd":140765779.55,"pct_val":2.6262733162,"balance":167389,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Novartis AG","title":"Novartis AG ADR-REP 1 CHF0.5 (REGD)","isin":"US66987V1098","value_usd":134007020.47,"pct_val":2.5001748519,"balance":971981,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Praxis Precision Medicines Inc","title":"Praxis Precision Medicines Inc COM NEW","isin":"US74006W2070","value_usd":127846127.66,"pct_val":2.3852308049,"balance":433759,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Boston Scientific Corporation","title":"Boston Scientific Corporation COM USD0.01","isin":"US1011371077","value_usd":125678260.55,"pct_val":2.3447848132,"balance":1318073,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Intuitive Surgical Inc.","title":"Intuitive Surgical Inc. COM USD0.001","isin":"US46120E6023","value_usd":123376995.12,"pct_val":2.3018500033,"balance":217842,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Thermo Fisher Scientific Inc","title":"Thermo Fisher Scientific Inc COM USD1","isin":"US8835561023","value_usd":122932055.85,"pct_val":2.2935487518,"balance":212153,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Sanofi SA","title":"Sanofi SA EUR2","isin":"FR0000120578","value_usd":122338850.44,"pct_val":2.2824812925,"balance":1261100,"units":"NS","currency":null,"asset_cat":"EC","issuer_cat":"CORP","inv_country":"FR","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"Amgen Inc.","title":"Amgen Inc. COM USD0.0001","isin":"US0311621009","value_usd":114901520.88,"pct_val":2.143722709,"balance":351048,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Roche Holding AG","title":"Roche Holding AG GENUSSCHEINE NPV","isin":"CH0012032048","value_usd":113869638.68,"pct_val":2.1244708376,"balance":275465,"units":"NS","currency":null,"asset_cat":"EP","issuer_cat":"CORP","inv_country":"CH","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"Bridgebio Pharma Inc","title":"Bridgebio Pharma Inc COM USD0.001","isin":"US10806X1028","value_usd":113013057.12,"pct_val":2.1084895579,"balance":1477488,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Vertex Pharmaceuticals Incorporated","title":"Vertex Pharmaceuticals Incorporated COM USD0.01","isin":"US92532F1003","value_usd":109029453.12,"pct_val":2.0341672836,"balance":240492,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"HCA Healthcare Inc","title":"HCA Healthcare Inc COM USD0.01","isin":"US40412C1018","value_usd":104868894.36,"pct_val":1.9565435565,"balance":224626,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Revolution Medicines Inc","title":"Revolution Medicines Inc COM","isin":"US76155X1000","value_usd":103106526.75,"pct_val":1.9236629868,"balance":1294495,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Danaher Corporation","title":"Danaher Corporation COM USD0.01","isin":"US2358511028","value_usd":95091994.48,"pct_val":1.7741355071,"balance":415394,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Stryker Corporation","title":"Stryker Corporation COM USD0.10","isin":"US8636671013","value_usd":87626040.11,"pct_val":1.6348428693,"balance":249313,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"CVS Health Corp","title":"CVS Health Corp COM USD0.01","isin":"US1266501006","value_usd":81067430.4,"pct_val":1.5124786006,"balance":1021515,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Ascendis Pharma A/S","title":"Ascendis Pharma A/S SPON ADR EACH REP 1 ORD SHS","isin":"US04351P1012","value_usd":80121518.16,"pct_val":1.4948306745,"balance":375734,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Madrigal Pharmaceuticals Inc","title":"Madrigal Pharmaceuticals Inc USD0.0001","isin":"US5588681057","value_usd":76387867.16,"pct_val":1.4251717843,"balance":131174,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Mckesson Corp.","title":"Mckesson Corp. COM USD0.01","isin":"US58155Q1031","value_usd":68365429.47,"pct_val":1.2754968128,"balance":83343,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Globus Med Inc","title":"Globus Med Inc COM USD0.001 CL 'A'","isin":"US3795772082","value_usd":65807380.51,"pct_val":1.2277711813,"balance":753721,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Teva Pharmaceutical Industries Ltd.","title":"Teva Pharmaceutical Industries Ltd. SPON ADS EACH REP 1 ORD SHS","isin":"US8816242098","value_usd":63827446.16,"pct_val":1.1908314594,"balance":2045096,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Medtronic PLC","title":"Medtronic PLC USD0.0001","isin":"IE00BTN1Y115","value_usd":61945251.6,"pct_val":1.155715273,"balance":644860,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Elevance Health Inc.","title":"Elevance Health Inc. COM USD0.01","isin":"US0367521038","value_usd":59239444.5,"pct_val":1.1052329114,"balance":168990,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Gilead Sciences Inc.","title":"Gilead Sciences Inc. COM USD0.001","isin":"US3755581036","value_usd":58792091.78,"pct_val":1.0968866321,"balance":478997,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"PTC Therapeutics, Inc.","title":"PTC Therapeutics, Inc. COM USD0.001","isin":"US69366J2006","value_usd":58085776.44,"pct_val":1.0837088759,"balance":764689,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Travere Therapeutics Inc","title":"Travere Therapeutics Inc COM","isin":"US89422G1076","value_usd":54915068.11,"pct_val":1.0245528316,"balance":1437191,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Cencora Inc","title":"Cencora Inc COM USD0.01","isin":"US03073E1055","value_usd":54690844.25,"pct_val":1.0203694773,"balance":161927,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Mirum Pharmaceuticals Inc.","title":"Mirum Pharmaceuticals Inc. COM USD0.0001","isin":"US6047491013","value_usd":53925841.08,"pct_val":1.0060967796,"balance":682692,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Avidity Biosciences Inc.","title":"Avidity Biosciences Inc. COM","isin":"US05370A1088","value_usd":52888673.33,"pct_val":0.9867462954,"balance":733241,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"United Therapeutics Corporation","title":"United Therapeutics Corporation COM USD0.01","isin":"US91307C1027","value_usd":52098719,"pct_val":0.9720080829,"balance":106924,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Dyne Therapeutics Inc.","title":"Dyne Therapeutics Inc. COM","isin":"US26818M1080","value_usd":49275884.52,"pct_val":0.9193423363,"balance":2519217,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Soleno Therapeutics Inc","title":"Soleno Therapeutics Inc COM","isin":"US8342033094","value_usd":46391812.9,"pct_val":0.8655340858,"balance":1001983,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Vaxcyte Inc","title":"Vaxcyte Inc COM","isin":"US92243G1085","value_usd":44927210.1,"pct_val":0.8382089272,"balance":973715,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"JANUS CAPITAL GROUP INC","title":"Janus Henderson Cash Liquidity Fund LLC","isin":null,"value_usd":40183522.12,"pct_val":0.7497057327,"balance":40171470.6742,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"PF","inv_country":"US","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"Structure Therapeutics Inc","title":"Structure Therapeutics Inc SPONSORED ADS","isin":"US86366E1064","value_usd":39941730.4,"pct_val":0.745194614,"balance":574288,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Edwards Lifesciences Corporation","title":"Edwards Lifesciences Corporation COM USD1","isin":"US28176E1082","value_usd":39459752.75,"pct_val":0.7362023358,"balance":462871,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Medline Inc.","title":"Medline Inc. COM CL A","isin":"US58507V1070","value_usd":36923208,"pct_val":0.6888779093,"balance":879124,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"UCB SA","title":"UCB SA NPV","isin":"BE0003739530","value_usd":36563544.57,"pct_val":0.6821676529,"balance":131102,"units":"NS","currency":null,"asset_cat":"EC","issuer_cat":"CORP","inv_country":"BE","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"Daiichi Sankyo Co Ltd.","title":"Daiichi Sankyo Co Ltd. NPV","isin":"JP3475350009","value_usd":35096624.18,"pct_val":0.654799255,"balance":1647700,"units":"NS","currency":null,"asset_cat":"EC","issuer_cat":"CORP","inv_country":"JP","fair_val_level":"2","payoff_profile":"Long"},{"issuer_name":"Lantheus Holdings Inc","title":"Lantheus Holdings Inc COM USD0.01","isin":"US5165441032","value_usd":34955919.9,"pct_val":0.652174129,"balance":525258,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Becton, Dickinson and Company","title":"Becton, Dickinson and Company COM USD1.00","isin":"US0758871091","value_usd":32395716.96,"pct_val":0.6044083106,"balance":166928,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Penumbra Inc.","title":"Penumbra Inc. COM USD0.001","isin":"US70975L1070","value_usd":31128620.11,"pct_val":0.5807680292,"balance":100121,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Apogee Therapeutics Inc.","title":"Apogee Therapeutics Inc. COM","isin":"US03770N1019","value_usd":28550913.84,"pct_val":0.5326756504,"balance":378258,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"DexCom Inc","title":"DexCom Inc COM USD0.001","isin":"US2521311074","value_usd":28135835.88,"pct_val":0.5249315227,"balance":423924,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"IDEAYA Biosciences Inc.","title":"IDEAYA Biosciences Inc. COM USD0.0001","isin":"US45166A1025","value_usd":26388145.25,"pct_val":0.492324782,"balance":763325,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"The Cooper Companies, Inc.","title":"The Cooper Companies, Inc. COM","isin":"US2166485019","value_usd":26314733.28,"pct_val":0.4909551317,"balance":321068,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Glaukos Corp.","title":"Glaukos Corp. COM USD0.001","isin":"US3773221029","value_usd":24833312.49,"pct_val":0.4633161991,"balance":219939,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Tarsus Pharmaceuticals Inc","title":"Tarsus Pharmaceuticals Inc COM","isin":"US87650L1035","value_usd":22578000.6,"pct_val":0.4212387464,"balance":275745,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Steris PLC","title":"Steris PLC ORD USD0.001","isin":"IE00BFY8C754","value_usd":20693570,"pct_val":0.3860808421,"balance":81625,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Rhythm Pharmaceuticals Inc","title":"Rhythm Pharmaceuticals Inc COM USD0.001","isin":"US76243J1051","value_usd":20469794.4,"pct_val":0.3819058509,"balance":191235,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Neurocrine Biosciences Inc","title":"Neurocrine Biosciences Inc COM USD0.001","isin":"US64125C1099","value_usd":19685436.68,"pct_val":0.3672720546,"balance":138796,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"HeartFlow Inc","title":"HeartFlow Inc - Series F","isin":"DU0000106398","value_usd":19307036.1,"pct_val":0.3602122184,"balance":662334,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Nuvalent Inc","title":"Nuvalent Inc COM","isin":"US6707031075","value_usd":18758827.92,"pct_val":0.3499842744,"balance":186488,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Sotera Health Company","title":"Sotera Health Company COM","isin":"US83601L1026","value_usd":18596987.64,"pct_val":0.3469648132,"balance":1054251,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Regeneron Pharmaceuticals, Inc.","title":"Regeneron Pharmaceuticals, Inc. COM USD0.001","isin":"US75886F1075","value_usd":18470077.23,"pct_val":0.3445970401,"balance":23929,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Alnylam Pharmaceuticals Inc.","title":"Alnylam Pharmaceuticals Inc. COM USD0.01","isin":"US02043Q1076","value_usd":18223504.2,"pct_val":0.3399967163,"balance":45828,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Ardelyx Inc","title":"Ardelyx Inc COM USD0.0001","isin":"US0396971071","value_usd":18130518.78,"pct_val":0.3382618832,"balance":3109866,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Zoetis Inc.","title":"Zoetis Inc. COM USD0.01 CL 'A'","isin":"US98978V1035","value_usd":16974502.02,"pct_val":0.3166940279,"balance":134911,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Olema Pharmaceuticals Inc.","title":"Olema Pharmaceuticals Inc. COM","isin":"US68062P1066","value_usd":16672825,"pct_val":0.3110656265,"balance":666913,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Edgewise Therapeutics Inc.","title":"Edgewise Therapeutics Inc. COM","isin":"US28036F1057","value_usd":15326414.01,"pct_val":0.2859455777,"balance":617627,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Scholar Rock Holding Corp.","title":"Scholar Rock Holding Corp. COM USD0.001","isin":"US80706P1030","value_usd":14998320.2,"pct_val":0.2798243171,"balance":340484,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Cogent Biosciences Inc.","title":"Cogent Biosciences Inc. COM","isin":"US19240Q2012","value_usd":14522494.08,"pct_val":0.2709468083,"balance":408854,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Xenon Pharmaceuticals Inc","title":"Xenon Pharmaceuticals Inc COM NPV","isin":"CA98420N1050","value_usd":14012345.52,"pct_val":0.2614289443,"balance":312636,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Insmed Inc","title":"Insmed Inc COM USD0.01","isin":"US4576693075","value_usd":13998733.36,"pct_val":0.2611749816,"balance":80434,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Centene Corp.","title":"Centene Corp. COM USD0.001","isin":"US15135B1017","value_usd":13976268.3,"pct_val":0.26075585,"balance":339642,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Crinetics Pharmaceuticals Inc.","title":"Crinetics Pharmaceuticals Inc. COM USD0.001","isin":"US22663K1079","value_usd":13955736.55,"pct_val":0.2603727882,"balance":299801,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Protagonist Therapeutics Inc","title":"Protagonist Therapeutics Inc COM USD0.00001","isin":"US74366E1029","value_usd":13950818.2,"pct_val":0.2602810264,"balance":159730,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Terns Pharmaceuticals Inc.","title":"Terns Pharmaceuticals Inc. COM","isin":"US8808811074","value_usd":13717133.2,"pct_val":0.2559211551,"balance":339533,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Humana Inc.","title":"Humana Inc. COM USD0.166","isin":"US4448591028","value_usd":13460399.89,"pct_val":0.2511312705,"balance":52553,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Inspire Medical Systems Inc","title":"Inspire Medical Systems Inc COM USD0.001","isin":"US4577301090","value_usd":13368000.66,"pct_val":0.249407374,"balance":144942,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Illumina Inc","title":"Illumina Inc COM USD0.01","isin":"US4523271090","value_usd":13358777.16,"pct_val":0.2492352907,"balance":101851,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Arcellx Inc","title":"Arcellx Inc COMMON STOCK","isin":"US03940C1009","value_usd":13319251.6,"pct_val":0.2484978606,"balance":204283,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Teleflex Incorporated","title":"Teleflex Incorporated COM USD1","isin":"US8793691069","value_usd":12332386.08,"pct_val":0.2300858674,"balance":101052,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD","title":"Kardium Inc - Series 8 Class D Preferred shares","isin":"DU0US0007846","value_usd":12237311.62,"pct_val":0.228312059,"balance":13234820,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"CA","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Insulet Corporation","title":"Insulet Corporation COM STK USD0.001","isin":"US45784P1012","value_usd":10353726.24,"pct_val":0.1931699241,"balance":36426,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Avadel Pharmaceuticals PLC","title":"Avadel Pharmaceuticals PLC COM SHS","isin":"IE00BDGMC594","value_usd":10273833.2,"pct_val":0.1916793561,"balance":476744,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Janux Therapeutics Inc","title":"Janux Therapeutics Inc COM","isin":"US47103J1051","value_usd":9922545,"pct_val":0.1851253568,"balance":719025,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Immunome Inc","title":"Immunome Inc COM","isin":"US45257U1088","value_usd":7908313.08,"pct_val":0.1475457436,"balance":368171,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"4D Molecular Therapeutics Inc","title":"4D Molecular Therapeutics Inc COM","isin":"US35104E1001","value_usd":6318900,"pct_val":0.1178919941,"balance":842520,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Lexeo Therapeutics Inc","title":"Lexeo Therapeutics Inc COM","isin":"US52886X1072","value_usd":6281241.36,"pct_val":0.1171893952,"balance":632552,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Green Cross Holdings Corp","title":"Curevo Inc","isin":"DU0000105594","value_usd":5330344.1,"pct_val":0.0994484634,"balance":2031087,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD","title":"HeartFlow Inc","isin":"DU0US0008223","value_usd":3835440.4,"pct_val":0.0715579796,"balance":131576,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Loadsmart Inc","title":"Curevo Inc - Series B","isin":"DU0US0007660","value_usd":3538210.11,"pct_val":0.066012541,"balance":1348208,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Magnolia Medical Technologies","title":"Magnolia Medical Technologies","isin":"DU0000105101","value_usd":3096918.9,"pct_val":0.0577793516,"balance":1821717,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Element Biosciences Inc","title":"Element Biosciences Inc","isin":"DU0000104465","value_usd":2461308.19,"pct_val":0.0459207347,"balance":425023,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Green Cross Holdings Corp","title":"Curevo Inc - Series B-1","isin":"DU0US0007429","value_usd":2327231.95,"pct_val":0.0434192685,"balance":886774,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Sonoma Biotherapeutics Inc","title":"Sonoma Biotherapeutics Inc - Series B","isin":"DU0000104500","value_usd":1970664,"pct_val":0.0367667646,"balance":1255200,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"PFIZER INC","title":"PFIZER INC-CVR","isin":"DU0US0005090","value_usd":1915757.9,"pct_val":0.0357423791,"balance":390971,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Twinstrand Biosciences Inc","title":"TwinStrand Biosciences Inc","isin":"DU0000104396","value_usd":1380526.98,"pct_val":0.0257565523,"balance":344314,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Align Technology Inc.","title":"Align Technology Inc. COM USD0.0001","isin":"US0162551016","value_usd":1137865.05,"pct_val":0.0212291981,"balance":7287,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Sonoma Biotherapeutics Inc","title":"Sonoma Biotherapeutics Inc - Series B-1","isin":"DU0000106193","value_usd":1051001.96,"pct_val":0.0196085896,"balance":669428,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Freenome Holdings Inc","title":"Freenome Holdings Inc - Series D","isin":"DU0000104596","value_usd":1016205.21,"pct_val":0.0189593851,"balance":342803,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Freenome Holdings Inc","title":"Freenome Holdings Inc - Series C","isin":"DU0000103893","value_usd":997910.62,"pct_val":0.0186180622,"balance":337474,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Asher Biotherapeutics Inc","title":"Asher Biotherapeutics - Series C","isin":"DU0US0006305","value_usd":809963.05,"pct_val":0.0151115161,"balance":2580733,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Attralus Inc","title":"Attralus Inc","isin":"DU0000104336","value_usd":415359.7,"pct_val":0.0077493841,"balance":669935,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Hemoshear Therapeutics LLC","title":"Magnolia Medical Technologies","isin":"DU0US0010115","value_usd":411789.81,"pct_val":0.0076827805,"balance":301933,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD","title":"HeartFlow Inc","isin":"DU0000106284","value_usd":399325.85,"pct_val":0.0074502399,"balance":13699,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"1","payoff_profile":"Long"},{"issuer_name":"Asher Biotherapeutics Inc","title":"Asher Biotherapeutics Inc","isin":"DU0000101918","value_usd":381108.37,"pct_val":0.0071103556,"balance":1214301,"units":"NS","currency":"USD","asset_cat":"EP","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Novo Nordisk A/S","title":"NOVO NORDISK A/S - CVR","isin":"DU0US0008635","value_usd":370032.65,"pct_val":0.0069037154,"balance":569281,"units":"NS","currency":"USD","asset_cat":null,"issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"},{"issuer_name":"Magnolia Medical Technologies","title":"Magnolia Medical Technologies","isin":"DU0000105108","value_usd":0,"pct_val":0,"balance":1,"units":"NS","currency":"USD","asset_cat":"EC","issuer_cat":"CORP","inv_country":"US","fair_val_level":"3","payoff_profile":"Long"}],"source_documents":[{"label":"SEC NPORT-P Filings","url":"https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=277751&type=NPORT&dateb=&owner=exclude&count=40"}],"dataset":{"json":"https://dealcharts.org/llm/facts/fund/janus-henderson-global-life-sciences-fund.json","page":"https://dealcharts.org/capitalmarkets/funds/janus-henderson-global-life-sciences-fund/"},"provenance":{"curator":"CMD+RVL","curator_url":"https://cmdrvl.com","platform":"Dealcharts","platform_url":"https://dealcharts.org/","source":"SEC NPORT-P Public Filings","license":"CC-BY 4.0","license_url":"https://creativecommons.org/licenses/by/4.0/","attribution":"Data curated by CMD+RVL from SEC NPORT-P public filings"},"citation":"Fund: Janus Henderson Global Life Sciences Fund | LEI: 5493001MPP2BKRJEGV73 | 106 positions totaling $5,352,958,219 across EP, EC | Filing: Thu Feb 26 2026 19:00:00 GMT-0500 (Eastern Standard Time) | Source: SEC NPORT-P via Dealcharts.org","updated_at":"2026-02-27"}
